The incident reportedly occurred in Runaway Bay, St Ann on Wednesday morning.
The dead man remains unidentified, but the identity of the accused woman, believed to be a sex worker has been withheld by the police.
Indications are that the man and woman got into a fuss after they reportedly engaged in a sex act, for which the man was required to pay a sum of money.
However, at the end of the act, he sought to forcefully renege on the arrangement by taking back his money at knifepoint.
It was reported that in a rage, the woman used a knife to stab the man in his upper back while police personnel were searching him.
The man was taken to the St Ann’s Bay Hospital, where he was pronounced dead, while the woman was taken into police custody.